Nuclear Magnetic Resonance and Nucleic Acids
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These proteins shares some features with the bacterial and human MUTS proteins, and is predicted to contribute to mismatch repair in the mitochondria. The desired candidate will have experience in molecular biology and protein expression. Recent graduates with less than three years experience are encouraged to apply, and those will more experience will also be considered.
This year our proposal was one of 25 awards that were granted worldwide.
The lab is focussed on the structural details of how proteins and nucleic acids come together to form complexes. Current projects include: Proteins involved in RNA processing, especially alternative splicing. Synthetic foldamer recognition of biomolecules.
Nucleic acid recognition by proteins. A new domain for binding double-stranded RNA. Recent work from a long-standing collaboration with the group of Chris Nelson Univ. Victoria, Canada has revealed an RNA-binding behaviour for a nuclear proline isomerase. This association with RNA is required to mediate interactions with several proteins involved in ribosome biogenesis.
Dilworth, D. Nucleic Acids.
Nucleic acids and nuclear magnetic resonance.
The difference that a 'G' makes. Using X-ray crystallography, PhD student Heddy Soufari has determined the atomic details of the nucleic acid binding properties of this domain from nematode MEC Using an extensive set of RNA binding studies with C. The initial 'G' is specifically recognized via several key hydrogen bonds between the RNA base and the protein. Due to dimerization, the optimal target is actually two copies of GCAC separated by at least 6 nucleotides.
NUCLEIC ACIDS: A NUCLEAR MAGNETIC RESONANCE STUDY.
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Nuclear Magnetic Resonance and Nucleic Acids, Volume 261
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